Fmoc-β-Ala-Ser(tBu)-OH Peptide Standard KSM HPLC 99+

1. Solid-Phase Peptide Synthesis (SPPS)
Widely used in Solid-Phase Peptide Synthesis as a pre-assembled β-Ala–Ser dipeptide building block.

• Fmoc group provides N-terminal protection
• C-terminal –COOH enables further peptide elongation
• Reduces coupling steps and improves synthesis efficiency

2. Introduction of Hydroxyl Functionality
Serine (Ser) contains a hydroxyl group that can:

• increase peptide polarity
• enhance hydrogen bonding interactions
• influence peptide conformation and solubility

Commonly used in:

• bioactive peptides
• receptor-binding sequences
• functional peptide design

3. Side-Chain Protection Strategy
The Ser(tBu) residue provides:

• protection of the hydroxyl group during synthesis
• prevention of undesired side reactions
• clean deprotection under acidic conditions (e.g., TFA)

4. Flexible Spacer Function (β-Ala)
The β-alanine residue acts as a flexible spacer.

Benefits include:

• increased backbone flexibility
• reduced steric hindrance
• optimized spatial arrangement of functional residues

Useful in:

• linker design
• peptide conjugates
• sequence optimization

5. Functional Peptide and Research Applications
Fmoc-β-Ala-Ser(tBu)-OH is commonly used in the preparation of:

• functional peptides
• peptide analogs
• research peptides
• peptide libraries

The Ser residue contributes to hydrogen bonding and structural modulation.