Fmoc-β-Ala-Arg(Pbf)-OH Solid-phase Peptide Synthesis

High-purity Fmoc-β-Ala-Arg(Pbf)-OH for Impurity Research and pharmaceutical development.

The primary use is in Solid-Phase Peptide Synthesis.

Functions:

• Acts as a pre-assembled dipeptide fragment (β-Ala-Arg)
• Fmoc protects the N-terminus during chain elongation
• Arg(Pbf) protects the guanidine side chain of arginine
• C-terminal –COOH allows further coupling

Advantages:

• reduces coupling steps
• improves synthesis efficiency
• prevents side reactions on the arginine side chain

This building block is used to synthesize bioactive and therapeutic peptides.

Why it is useful:

• Arginine residues often participate in receptor binding or cell penetration
• β-Alanine adds flexibility to peptide structure
• improves peptide solubility and biological activity

Typical areas:

• hormone analogs
• receptor ligands
• peptide inhibitors

Arginine-rich sequences are commonly used in cell-penetrating peptides.

The Arg residue:

• enhances membrane interaction
• improves cell uptake of peptides

Therefore this fragment can be used in the design of:

• drug delivery peptides
• peptide transport systems

The β-Ala spacer provides flexibility and spacing in peptide structures.

Applications:

• peptide–drug conjugates
• peptide–fluorophore probes
• peptide–carrier systems

Small packages (1g, 25g, 1Kg, 25Kg) can be shipped by Express (DHL, FedEx, EMS, etc.). Large packages (100kg and more than 100Kg) can be transported by Air or Sea. All transportation is arranged according to customer requirements.